The MIT COVID-19 Challenge harnessed the passion, enthusiasm and expertise of thousands of innovators world-wide via a series of virtual hackathons that resulted in initiatives that address the many challenges related to COVID-19. The MIT COVID-19 Challenge was launched in March 2020 at the beginning of the COVID-19 pandemic. This initiative was built by members of the MIT community with the foundational support of the MIT Innovation Initiative, Martin Trust Center for Entrepreneurship, and MIT Hacking Medicine.